Michael Rupp, Kris Letang and Alex Goligoski also scored for the Penguins, who won in California for just the second time since January 1999 with two goals in the third period.
Marc-Andre Fleury made 26 saves for the Penguins, who matched the seven season-opening road victories of the 1940 Toronto Maple Leafs, the 1985 Philadelphia Flyers and the 2005 Detroit Red Wings. New Jersey also is 7-0 on the road so far this season.
Corey Perry scored two goals for the Ducks, who have lost six of seven. The Ducks' slow start hasn't affected the talented young forward, who scored his 100th career goal while extending his six-game scoring streak and a career-best four-game goal streak.
Pittsburgh was winless in 14 of its last 15 games in California. The Penguins visit Los Angeles on Thursday and San Jose on Saturday.
Jonas Hiller stopped 23 shots and Saku Koivu scored his first goal since Oct. 6 for Anaheim, but Pittsburgh opened its four-game West Coast road trip by causing constant traffic in front of the Ducks' net.
Perhaps that's because the Ducks also played without defenseman James Wisniewski, who sat out the first game of a two-game suspension for a high hit on Phoenix captain Shane Doan last weekend. Wisniewski has averaged nearly 25½ minutes per game for Anaheim this season.
Letang's first goal of the season put the Penguins ahead 2-1 during a delayed penalty on the Ducks, but Perry tied it six minutes later in the second period when two defenders couldn't stop him from slamming a rebound underneath Fleury.
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